Dickensian Diagnoses

A Dickensian origin for Sherrington's enchanted loom?

Sherrington's image of the mind-brain as an 'enchanted loom' has intrigued scientists for decades. Its origin, however, has been unclear. Here, we make a new suggestion as to where it may have come from. The article sheds light on the connections between literary and scientific similes and metaphors.

Trauma, memory, and railway disaster: the Dickensian Connection.

Mistaken Diagnoses

(1) Chocolate cysts of the ovary Mrs. M., aged 20 years, married six months ago, was admitted for severe pain in the lower abdomen followed by red discharge per vagina since the previous night. The last period was 25 days ago. General condition good. Pulse 90 per minute. Heart and lungs nothing abnormal detected. P.V.?Os closed. Uterus pushed to the right by a slightly movable tender swelling i...

Characterizing Diagnoses

Most approaches to model-based diagnosis describe a diagnosis for a system as a set of failing components that explains the symptoms. In order to characterize the typically very large number of diagnoses, usually only the minimal such sets of failing components are represented. This method of characterizing all diagnoses is inadequate in general, in part because not every superset of the faulty...

Skin Diseases: DNA-Based Diagnoses and Prenatal Diagnoses

Among a range of inherited skin disorders, some of markedly severe phenotypes have been widely considered as indications for prenatal diagnoses. Recent studies have achieved significant progress in understanding the molecular basis of these heritable skin discases. These include epidermolysis bullosa (EB). a group ef mechanobullous genodermatoses, ichthyosis, a heterogeneous condition of gcnera...